Genome-wide Association Study of Alzheimer's disease with Psychotic Symptoms
Using Multifactor Dimensionality Reduction Analysis 
   Lead Investigator:    Young Min Lee
   Institution      :    U California, Davis
   E-Mail           :    psyleekr@naver.com
   Proposal ID      :    808



   Proposal Description:
   Psychotic symptoms occur in approximately 40 of subjects with Alzheimer?s disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61 and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. But, it has been known that AD gene do not themselves cause psychosis of AD, but may affect expression of AD psychosis gene. It is possible that AD gene and psychosis gene in AD may have epistasis (gene-gene interaction) each other. The aim of this study is to investigate the association between genetic variants and psychotic symptoms in sporadic AD patients by using Multifactor Dimensionality Reduction (MDR) to assess epistasis in sporadic AD